Description

tert-Butyl 3-(3,3-Difluoropyrrolidin-1-yl)azetidine-1-carboxylate is a high-value, multifunctional heterocyclic building block of significant interest in modern synthetic chemistry. This compound, with CAS number 1257294-09-9, is prized for its unique structural features, including the azetidine and difluoropyrrolidine motifs, which are crucial for modulating the physicochemical and pharmacokinetic properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used as a versatile scaffold for constructing novel herbicides, fungicides, and insecticides, where the fluorine atoms and constrained ring systems can enhance biological activity and environmental stability.
• Chemical Biology Probe Development: Serves as a core structure for creating tool compounds and probes to study enzyme function and biological pathways.
• Ligand and Catalyst Design: Employed in the synthesis of sophisticated ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Advanced Material Precursor: Potential use in the synthesis of specialty polymers and functional materials that require specific fluorine-containing heterocycles.

Basic Information

Product Name	tert-Butyl 3-(3,3-Difluoropyrrolidin-1-yl)azetidine-1-carboxylate
CAS No.	1257294-09-9
Molecular Formula	C12H20F2N2O2
Molecular Weight	262.30 g/mol
Synonyms	1-Boc-3-(3,3-difluoropyrrolidin-1-yl)azetidine; 3-(3,3-Difluoropyrrolidin-1-yl)azetidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-(3,3-difluoro-1-pyrrolidinyl)-1-azetidinecarboxylate; 1-(1-(tert-Butoxycarbonyl)azetidin-3-yl)-3,3-difluoropyrrolidine; 1257294-09-9; Azetidine, 3-(3,3-difluoro-1-pyrrolidinyl)-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(3,3-Difluoropyrrolidin-1-yl)azetidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistent quality suitable for research and scale-up applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.