Description

5-(Trifluoromethyl)-1H-Pyrazolo[4,3-B]Pyridine is a high-value, heterocyclic organic compound featuring a fused pyrazolopyridine core substituted with a trifluoromethyl group. This unique structure makes it a critical pharmaceutical intermediate and building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to incorporate fluorine-containing motifs into novel active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for advanced organic electronic materials, such as ligands for OLEDs or charge-transport materials.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and for creating focused libraries for high-throughput screening.
• Chemical Biology: Used as a probe or tag in biochemical assays due to its distinct physicochemical properties.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis and scale-up projects.

Basic Information

Product Name	5-(Trifluoromethyl)-1H-Pyrazolo[4,3-B]Pyridine
CAS No.	1256836-65-3
Molecular Formula	C7H4F3N3
Molecular Weight	187.12 g/mol
Synonyms	1H-Pyrazolo[4,3-b]pyridine, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine; 5-Trifluoromethyl-1H-pyrazolo[4,3-b]pyridine; 5-(Trifluoromethyl)pyrazolo[4,3-b]pyridine; 1H-Pyrazolo[4,3-b]pyridine, 5-(trifluoromethyl)-; 1256836-65-3; AKOS026714023; Z57127455
EINECS	Contact for details

Quality Control

Every batch of 5-(Trifluoromethyl)-1H-Pyrazolo[4,3-B]Pyridine is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.