Description

Landiolol Hydrochloride Enantiomerⅱ（Benzenepropanoic Acid is a high-purity, single-enantiomer pharmaceutical intermediate of significant importance in modern drug development. This compound is critical for the synthesis of the ultra-short-acting, cardioselective β-blocker Landiolol, enabling precise pharmacological targeting and improved therapeutic profiles. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on developing and producing advanced cardiovascular medications and other specialized therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of the active pharmaceutical ingredient (API) Landiolol Hydrochloride.
• Cardiovascular Drug R&D: Used in research and development of ultra-short-acting, cardioselective β-adrenergic blocking agents.
• Chiral Synthesis Studies: Serves as a reference standard and starting material in stereoselective synthesis and process chemistry optimization.
• Analytical Reference Standard: Employed as a high-purity standard for HPLC, LC-MS, and other analytical methods in quality control and method development.
• Preclinical & Clinical Trial Material: Supplied as a critical raw material for producing batches intended for non-clinical and clinical studies.
• Process Development: Utilized in scaling up and optimizing manufacturing processes for Landiolol-based formulations.

Basic Information

Product Name	Landiolol Hydrochloride Enantiomerⅱ（Benzenepropanoic Acid
CAS No.	1253907-85-5
Molecular Formula	C₂₅H₃₄N₂O₄ • HCl
Molecular Weight	463.01 g/mol (Hydrochloride salt)
Synonyms	Landiolol Impurity; (S)-Landiolol Intermediate; Benzenepropanoic acid, α-[4-[(2-hydroxy-3-phenoxypropyl)amino]butyl]-, hydrochloride, (αS)-; UNII-9K7805510S; Landiolol Related Compound; Landiolol HCl Enantiomer; ONO-1101 Enantiomer; (S)-Form Landiolol Precursor
EINECS	Contact for details

Quality Control

Our Landiolol Hydrochloride Enantiomerⅱ is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP, ICH Q7, and other relevant regulatory guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.