Description

Landiolol Hydrochloride Enantiomerⅰ（Benzenepropanoic Acid,4-[(2R)-2-Hydroxy-3-[[2-[(4-Morpholinylcarbonyl)Amino]Ethyl]Amino]Propoxy]- is a high-purity, single-enantiomer pharmaceutical intermediate and reference standard. This compound is the CAS NO 1253907-83-3 enantiomer of the ultra-short-acting, cardioselective β-1 adrenergic receptor antagonist Landiolol. It is critical for pharmaceutical R&D, process development, and analytical method validation, enabling the production of safer and more effective cardiovascular drugs with precise stereochemical control.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis: A key chiral building block for the production of the ultra-short-acting β-blocker Landiolol hydrochloride.
• Reference Standard for Analytical Testing: Used in HPLC, LC-MS, and chiral chromatography for method development, validation, and quality control of pharmaceutical batches.
• Pharmacological Research & Development: Employed in preclinical and clinical studies to investigate the stereospecific pharmacokinetics, metabolism, and receptor binding affinity of β-blockers.
• Process Chemistry & Impurity Profiling: Serves as a critical standard for identifying and quantifying enantiomeric impurities during API manufacturing to ensure regulatory compliance.
• Academic Research: Used in university and institutional labs for studies in medicinal chemistry, cardiovascular pharmacology, and chiral drug design.

Basic Information

Item	Details
Product Name	Landiolol Hydrochloride Enantiomerⅰ（Benzenepropanoic Acid,4-[(2R)-2-Hydroxy-3-[[2-[(4-Morpholinylcarbonyl)Amino]Ethyl]Amino]Propoxy]-
CAS No.	1253907-83-3
Molecular Formula	C19H29N3O5 • HCl
Molecular Weight	431.91 g/mol (as hydrochloride salt)
Synonyms	(R)-Landiolol Hydrochloride; Landiolol (R)-Enantiomer Hydrochloride; ONO-1101 Enantiomer; 4-[(2R)-2-Hydroxy-3-[[2-[(4-Morpholinylcarbonyl)amino]ethyl]amino]propoxy]benzenepropanoic Acid Hydrochloride; (R)-ONO-1101; Esmolol analogue enantiomer; Ultra-short-acting β-1 blocker intermediate; Chiral β-adrenergic antagonist standard.
EINECS	Contact for details

Quality Control

We supply Landiolol Hydrochloride Enantiomerⅰ under a stringent quality management system. Our products undergo rigorous analytical testing, including chiral HPLC and spectroscopic methods, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each batch. We can support development with GMP-grade material and specifications tailored to your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.