Description

Landiolol Hydrochloride Enantiomerⅲ (Benzenepropanoic Acid) is a high-purity, single-isomer pharmaceutical intermediate and reference standard. This compound is critical for research and development in cardiovascular pharmacology, specifically for the study of ultra-short-acting β-1 adrenergic receptor antagonists. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions for the synthesis and analytical validation of novel cardioselective β-blockers.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of advanced β-blocker APIs, particularly Landiolol and its analogs.
• Reference Standard: Used in analytical method development and validation (HPLC, LC-MS) for quality control and regulatory submissions.
• Pharmacological Research: Essential for in-vitro and in-vivo studies investigating the mechanism, potency, and selectivity of β-1 adrenergic antagonists.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale production of enantiomerically pure cardiovascular drugs.
• Impurity Profiling: Serves as a critical marker for identifying and quantifying related substances and enantiomeric impurities in final drug products.

Basic Information

Product Name	Landiolol Hydrochloride Enantiomerⅲ (Benzenepropanoic Acid)
CAS No.	1253907-81-1
Molecular Formula	C₂₅H₃₄N₂O₄ • HCl
Molecular Weight	463.01 g/mol
Synonyms	Landiolol HCl Enantiomer III; (R)-Landiolol Hydrochloride; (R)-3-[4-[2-Hydroxy-3-[(2-morpholinoethyl)amino]propoxy]phenyl]propanoic acid hydrochloride; Benzenepropanoic acid derivative; ONO-1101 Enantiomer; Ultra-short-acting β-1 blocker intermediate
EINECS	Contact for details

Quality Control

Our Landiolol Hydrochloride Enantiomerⅲ is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and stringent control of residual solvents and heavy metals. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and can be tailored to meet specific pharmacopeial or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.