Description

Landiolol hydrochloride is a highly selective, ultra-short-acting β-1 adrenergic receptor antagonist. This compound is critical for providing rapid, precise, and controllable heart rate reduction in clinical settings. It is primarily required by pharmaceutical manufacturers and research institutions developing or producing injectable solutions for perioperative tachycardia and other acute cardiac conditions.

Application

• Active Pharmaceutical Ingredient (API) in injectable formulations for the management of intraoperative and postoperative tachycardia.
• Key intermediate in advanced pharmaceutical synthesis and process development.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Biochemical research tool for studying β-1 adrenergic receptor function and cardioselective blockade.
• Raw material for the preparation of clinical trial supplies and investigational new drugs (IND).

Basic Information

Product Name	Landiolol Hydrochloride
CAS No.	1253907-79-7
Molecular Formula	C25H36N2O4 • HCl
Molecular Weight	465.03 g/mol
Synonyms	Landiolol HCl; ONO-1101; (2S)-2-{4-[(2S)-2-Hydroxy-3-{[2-(4-morpholinylcarbonyl)phenyl]amino}propoxy]phenyl}acetamide Hydrochloride; 4-[2-Hydroxy-3-[[2-(4-morpholinylcarbonyl)phenyl]amino]propoxy]benzeneacetamide Hydrochloride; Landiolol Hydrochloride Hydrate (common form)
EINECS	Contact for details

Quality Control

Our Landiolol hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) with specifications for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.