Description

(2E)-3-(4-Bromo-2-Fluorophenyl)Prop-2-Enenitrile CAS NO 1251527-80-6 is a high-purity, halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which incorporates both bromine and fluorine substituents, making it a versatile intermediate for constructing complex molecules. This compound is primarily needed by research and development chemists and process scale-up teams within the pharmaceutical and agrochemical industries.

Application

This specialized chemical intermediate is designed for high-value synthesis applications where precise molecular architecture is critical.

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated and brominated phenyl ring.
• Material Science Precursor: Serves as a monomer or precursor in the development of advanced organic electronic materials, such as OLEDs or semiconductors, due to its conjugated system.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create more complex biaryl structures.
• Fluorine Chemistry Research: An important substrate for studying the effects of fluorine substitution on the reactivity, stability, and metabolic profile of organic molecules.
• Ligand and Catalyst Development: Utilized in the synthesis of novel chiral or non-chiral ligands for asymmetric catalysis and other synthetic transformations.

Basic Information

Item	Details
Product Name	(2E)-3-(4-Bromo-2-Fluorophenyl)Prop-2-Enenitrile
CAS No.	1251527-80-6
Molecular Formula	C9H5BrFN
Molecular Weight	226.05 g/mol
Synonyms	(E)-3-(4-Bromo-2-fluorophenyl)acrylonitrile; 4-Bromo-2-fluorocinnamonitrile; trans-3-(4-Bromo-2-fluorophenyl)-2-propenenitrile; (E)-3-(4-Bromo-2-fluorophenyl)-2-propenenitrile; 2-Fluoro-4-bromocinnamonitrile; (E)-3-(4-Bromo-2-fluorophenyl)acrylonitrile; (2E)-3-(4-Bromo-2-fluorophenyl)acrylonitrile; (E)-3-(4-Bromo-2-fluorophenyl)prop-2-enenitrile
EINECS	Contact for details

Quality Control

Our production of (2E)-3-(4-Bromo-2-Fluorophenyl)Prop-2-Enenitrile adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. All materials undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.