Description

5-(Bromomethyl)-2,3-Difluorobenzonitrile is a versatile and high-value fluorinated aromatic building block. This compound matters for its unique molecular architecture, combining a reactive bromomethyl handle with difluoro and nitrile substituents, enabling precise synthetic modifications. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery, particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in displays and lighting.
• Cross-Coupling Reactions: The bromomethyl group facilitates Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions for carbon-carbon bond formation.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers with tailored properties such as chemical resistance and specific optical characteristics.
• Chemical Biology Probe Development: Useful for labeling and modifying biomolecules due to its reactive site, aiding in proteomics and diagnostic assay development.

Basic Information

Product Name	5-(Bromomethyl)-2,3-Difluorobenzonitrile
CAS No.	1251459-54-7
Molecular Formula	C8H4BrF2N
Molecular Weight	232.03 g/mol
Synonyms	2,3-Difluoro-5-(bromomethyl)benzonitrile; 2,3-Difluoro-α-bromo-p-tolunitrile; 5-(Bromomethyl)-2,3-difluorobenzene carbonitrile; Benzonitrile, 5-(bromomethyl)-2,3-difluoro-; 2,3-Difluoro-5-(bromomethyl)phenyl cyanide
EINECS	Contact for details

Quality Control

Our 5-(Bromomethyl)-2,3-Difluorobenzonitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and available upon request, supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.