Description

3-Bromo-2,6-Difluorobenzonitrile is a high-purity, multi-functional aromatic building block featuring bromine, fluorine, and nitrile substituents. This compound is valued for its unique reactivity profile, enabling precise molecular construction in advanced chemical synthesis. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic cores for bioactivity or further functionalization.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and bromo groups contribute to potency and environmental stability.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations for carbon-carbon and carbon-heteroatom bond formation.
• Nucleophilic Aromatic Substitution: The fluorine atoms at the ortho positions to the nitrile are activated for substitution, allowing for the introduction of various nucleophiles.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for creating diverse compound libraries for drug discovery screening.

Basic Information

Product Name	3-Bromo-2,6-Difluorobenzonitrile
CAS No.	1250444-23-5
Molecular Formula	C7H2BrF2N
Molecular Weight	218.00 g/mol
Synonyms	2,6-Difluoro-3-bromobenzonitrile; Benzonitrile, 3-bromo-2,6-difluoro-; 3-Bromo-2,6-difluorobenzene carbonitrile; 3-Bromo-2,6-difluorophenyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-2,6-Difluorobenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.