Description

2-(3,5-Difluorophenyl)-2-Methylpropanenitrile is a high-purity, specialized organic nitrile building block featuring a difluorinated aromatic core. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical and agrochemical active ingredients. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluorophenyl group contributes to efficacy and environmental profile.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and liquid crystals, leveraging its aromatic and nitrile functionalities.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up campaigns in fine chemical production.

Basic Information

Product Name	2-(3,5-Difluorophenyl)-2-Methylpropanenitrile
CAS No.	1249436-65-4
Molecular Formula	C10H9F2N
Molecular Weight	181.18 g/mol
Synonyms	2-(3,5-Difluorophenyl)-2-methylpropionitrile; α,α-Dimethyl-3,5-difluorobenzeneacetonitrile; 2-Methyl-2-(3,5-difluorophenyl)propanenitrile; 3,5-Difluoro-α,α-dimethylbenzenecetonitrile; (3,5-Difluorophenyl)(cyano)dimethylmethane; 2-(3,5-Difluorophenyl)-2-cyanopropane; Isopropyl(3,5-difluorophenyl)acetonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-(3,5-Difluorophenyl)-2-Methylpropanenitrile is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity requirements suitable for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.