Description

5-(S)-Fluorowillardiine is a high-purity, fluorinated derivative of the natural neuroactive amino acid willardiine, serving as a potent and selective agonist for glutamate receptor subtypes. This compound is of significant value in advanced neuroscience research and pharmaceutical development, particularly for studying neurodegenerative diseases and pain pathways. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical suppliers focused on neuropharmacology and central nervous system (CNS) drug discovery.

Application

• Neuroscience Research: As a selective agonist for kainate and AMPA subtypes of ionotropic glutamate receptors (iGluRs) in electrophysiological and pharmacological studies.
• Neuropharmacology: A critical tool compound for investigating the role of specific glutamate receptors in synaptic transmission, plasticity, and excitotoxicity.
• Drug Discovery & Development: Used as a reference standard and a key intermediate or pharmacophore in the design of novel therapeutics targeting neurological disorders.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro binding assays to identify and characterize new modulators of glutamate receptors.
• Academic Research: Fundamental studies on the structure-activity relationships (SAR) of willardiine analogs and their interaction with receptor binding sites.

Basic Information

Product Name	5-(S)-Fluorowillardiine
CAS No.	1249343-86-9
Molecular Formula	C7H8FN3O4
Molecular Weight	217.16 g/mol
Synonyms	(S)-5-Fluorowillardiine; (S)-2-Amino-5-fluoropyrimidine-4,6(1H,5H)-dione-3-propanoic acid; 5-Fluoro-L-willardiine; 5-Fluorowillardiine; Willardiine, 5-fluoro-, L-; Fluorowillardiine; 5-FW; Glutamate receptor agonist 5-F-Will
EINECS	Contact for details

Quality Control

Our 5-(S)-Fluorowillardiine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (S-enantiomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.