Description

Chloro-(3-Trifluoromethyl-Phenyl)-Acetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the trifluoromethyl group imparts desirable metabolic stability and lipophilicity. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis in asymmetric synthesis.
• Material Science Research: Intermediate for creating fluorinated monomers and polymers with unique surface properties and chemical resistance.
• Organic Synthesis Building Block: Serves as a versatile electrophile in nucleophilic substitution reactions and a substrate for further functionalization (e.g., hydrolysis, reduction).

Basic Information

Product Name	Chloro-(3-Trifluoromethyl-Phenyl)-Acetonitrile
CAS No.	1247690-29-4
Molecular Formula	C9H5ClF3N
Molecular Weight	219.59 g/mol
Synonyms	2-Chloro-2-(3-(trifluoromethyl)phenyl)acetonitrile; α-Chloro-α-(3-trifluoromethylphenyl)acetonitrile; (3-Trifluoromethylphenyl)chloroacetonitrile; 3-Trifluoromethylphenylchloroacetonitrile; 2-Chloro-2-(3-trifluoromethylphenyl)ethanenitrile; 3-(Chlorocyanomethyl)benzotrifluoride
EINECS	Contact for details

Quality Control

Our Chloro-(3-Trifluoromethyl-Phenyl)-Acetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.