Description

3-Bromomethyl-2-Fluoro-Benzonitrile is a versatile and high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its reactive bromomethyl and cyano groups, which facilitate efficient derivatization and incorporation into complex molecular architectures. It is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel organic electronic materials, such as semiconductors and liquid crystals, due to its aromatic and electron-withdrawing characteristics.
• Custom Synthesis and Contract Manufacturing: An important starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Chemical Biology Probes: Utilized to create fluorescent tags or affinity probes for studying biological processes and target engagement.

Basic Information

Product Name	3-Bromomethyl-2-Fluoro-Benzonitrile
CAS No.	1246527-18-3
Molecular Formula	C9H5BrFN
Molecular Weight	214.05 g/mol
Synonyms	2-Fluoro-3-(bromomethyl)benzonitrile; 3-(Bromomethyl)-2-fluorobenzonitrile; 2-Fluoro-α-(bromomethyl)benzonitrile; Benzonitrile, 3-(bromomethyl)-2-fluoro-; 2-Fluoro-3-bromomethylbenzonitrile; 3-Bromomethyl-2-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 3-Bromomethyl-2-Fluoro-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.