Description

6-Difluorobenzonitrile is a versatile fluorinated aromatic nitrile building block essential for advanced organic synthesis. This high-purity intermediate is critical for introducing the difluorobenzene moiety into complex molecular architectures, enabling precise modulation of electronic and steric properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of specialty materials and liquid crystals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro group enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs).
• Organic Electronic Materials: Employed in the development of organic semiconductors, OLED materials, and other electronic chemicals.
• Polymer Modification: Acts as a monomer or modifier to introduce fluorine into polymers, improving their chemical resistance, thermal stability, and surface properties.
• General Organic Synthesis: A valuable reagent in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution for creating complex, fluorinated compounds.

Basic Information

Product Name	6-Difluorobenzonitrile
CAS No.	1242338-90-4
Molecular Formula	C7H3F2N
Molecular Weight	139.10 g/mol
Synonyms	2,6-Difluorobenzonitrile; 1,3-Difluoro-2-cyanobenzene; 2,6-Difluorophenyl cyanide; 2-Cyano-1,3-difluorobenzene; Benzonitrile, 2,6-difluoro-; 2,6-Difluorobenzene carbonitrile; 2,6-DFBN
EINECS	Contact for details

Quality Control

Our 6-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and lot-to-lot consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Melting Point	Contact for details
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.