Description

3-(Trifluoromethoxy)-D-Phenylalanine is a non-natural, fluorinated derivative of the D-enantiomer of the amino acid phenylalanine. This compound is a valuable chiral building block in medicinal chemistry and pharmaceutical research, where its trifluoromethoxy group imparts unique metabolic stability and lipophilicity to target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and metabolic disease research.
• Peptide Chemistry: Incorporation into custom peptides to enhance stability, modulate receptor binding affinity, and improve pharmacokinetic properties.
• Protease Inhibitor Development: Used in the design and synthesis of potent, selective inhibitors for various proteolytic enzymes.
• Chemical Biology & Probe Design: Serves as a building block for creating activity-based probes and other tools to study biological pathways.
• Agrochemical Research: Potential intermediate in the development of advanced pesticides and herbicides with improved efficacy.
• Material Science: Exploration in the synthesis of specialized polymers and advanced materials with specific surface properties.

Basic Information

Product Name	3-(Trifluoromethoxy)-D-Phenylalanine
CAS No.	1241681-55-9
Molecular Formula	C10H10F3NO3
Molecular Weight	249.19 g/mol
Synonyms	D-3-(Trifluoromethoxy)phenylalanine; (R)-2-Amino-3-[3-(trifluoromethoxy)phenyl]propanoic acid; (R)-3-(Trifluoromethoxy)phenylalanine; D-α-Amino-3-(trifluoromethoxy)benzenepropanoic acid; (R)-3-(Trifluoromethoxyl)phenylalanine; D-Phenylalanine, 3-(trifluoromethoxy)-; Fmoc-D-3-(Trifluoromethoxy)Phe-OH (protected form)
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) documenting identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.