Description

2,4-Difluoro-6-Methoxybenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring strategically placed fluorine and methoxy substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Serves as a crucial building block for creating new herbicides, fungicides, and insecticides, where the difluoro-methoxy pattern can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and in the synthesis of advanced materials with specific electronic characteristics.
• Organic Electronic Materials: A potential precursor for the synthesis of fluorinated organic semiconductors and charge-transport materials used in OLEDs and other electronic devices.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-directed custom synthesis projects at various scales.

Basic Information

Product Name	2,4-Difluoro-6-Methoxybenzonitrile
CAS No.	1240518-41-5
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	6-Methoxy-2,4-difluorobenzonitrile; 2,4-Difluoro-6-methoxybenzonitrile; Benzonitrile, 2,4-difluoro-6-methoxy-; 1240518-41-5; 2,4-Difluoro-6-methoxy-benzonitrile; 2,4-Difluoro-6-methoxybenzenecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-6-Methoxybenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up activities. A Certificate of Analysis (COA) detailing purity (typically by HPLC or GC), identity confirmation (by IR, NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥98.0% (Standard Grade)
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.