Description

2-Methoxy-5-(Pentafluorosulfur)Phenylacetonitrile is a specialized fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its unique combination of a pentafluorosulfur (SF5) group and a nitrile functionality, offering a powerful handle for constructing complex molecules with tailored electronic and physical properties. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as in materials science for developing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly where the metabolically stable and highly lipophilic SF5 group is desired to modulate bioavailability and binding affinity.
• Agrochemical Research: Used in the synthesis of next-generation herbicides, fungicides, and insecticides, where the SF5 moiety can enhance biological activity and environmental stability.
• Advanced Material Precursor: Serves as a monomer or building block for specialty polymers, liquid crystals, and electronic materials requiring specific dielectric and optical properties.
• Organic Synthesis Building Block: The nitrile group provides a versatile site for further transformations (hydrolysis, reduction, cycloaddition), enabling the construction of complex heterocycles and functionalized aromatics.
• Ligand and Catalyst Development: Employed in the design of novel ligands for catalysis, where the strong electron-withdrawing nature of the SF5 group can fine-tune metal center reactivity.

Basic Information

Product Name	2-Methoxy-5-(Pentafluorosulfur)Phenylacetonitrile
CAS No.	1240257-27-5
Molecular Formula	C9H6F5NOS
Molecular Weight	271.21 g/mol
Synonyms	2-Methoxy-5-(pentafluoro-λ6-sulfanyl)benzeneacetonitrile; (2-Methoxy-5-(pentafluorosulfanyl)phenyl)acetonitrile; 5-(Pentafluorosulfanyl)-2-methoxyphenylacetonitrile; α-(2-Methoxy-5-(pentafluorosulfanyl)phenyl)acetonitrile; SF5-Phenylacetonitrile Derivative; Pentafluorosulfanyl Anisole Acetonitrile
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(Pentafluorosulfur)Phenylacetonitrile is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture uptake. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.