Description

4-(Pentafluorosulfur)Phenylacetonitrile is a high-value fluorinated aromatic nitrile building block, distinguished by the unique pentafluorosulfur (SF5) functional group. This compound matters for its exceptional ability to impart high thermal stability, chemical inertness, and strong lipophilicity to advanced materials and active pharmaceutical ingredients. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty polymer industries for the synthesis of novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: A key synthon for developing novel active pharmaceutical ingredients (APIs), particularly in CNS and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and pesticides, where the SF5 group enhances bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a critical precursor for high-performance electronic materials, contributing to improved dielectric anisotropy and charge transport properties.
• Polymer Modification: Incorporated into specialty polymers to enhance their chemical resistance, thermal stability, and surface properties for demanding industrial applications.
• Ligand & Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, leveraging the strong electron-withdrawing nature of the SF5 moiety.
• Advanced Material Research: A valuable building block in academic and industrial R&D for exploring new fluorinated compounds with unique physical and chemical properties.

Basic Information

Product Name	4-(Pentafluorosulfur)Phenylacetonitrile
CAS No.	1240257-04-8
Molecular Formula	C8H4F5NS
Molecular Weight	241.18 g/mol
Synonyms	4-(SF5)Phenylacetonitrile; p-(Pentafluorosulfanyl)benzyl cyanide; (4-(Pentafluoro-λ6-sulfanyl)phenyl)acetonitrile; 4-(Pentafluorosulphanyl)phenylacetonitrile; 2-[4-(Pentafluorosulfur)phenyl]acetonitrile; SF5-Phenylacetonitrile; 4-SF5-Benzyl cyanide
EINECS	Contact for details

Quality Control

Our 4-(Pentafluorosulfur)Phenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.