Description

2-Methoxy-5-(Pentafluorosulfur)Benzonitrile is a high-value, fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its core value proposition lies in the unique combination of the pentafluorosulfur (SF5) group, a highly electronegative and lipophilic bioisostere, with a methoxy-substituted benzonitrile scaffold. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and optimization of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the metabolically stable SF5 moiety into drug candidates, potentially enhancing their lipophilicity, bioavailability, and binding affinity.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides where the SF5 group can improve pesticidal activity and environmental stability.
• Material Science Precursor: Serves as a specialized monomer or additive in the synthesis of advanced polymers, liquid crystals, or electronic materials requiring specific fluorine content.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitution, and cyano-group transformations to create complex, fluorinated molecular architectures.
• Life Science Probes: Potential use in designing molecular probes and imaging agents for biochemical and diagnostic applications due to its distinct physicochemical signature.

Basic Information

Product Name	2-Methoxy-5-(Pentafluorosulfur)Benzonitrile
CAS No.	1240256-84-1
Molecular Formula	C8H4F5NOS
Molecular Weight	257.18 g/mol
Synonyms	5-(Pentafluoro-λ6-sulfanyl)-2-methoxybenzonitrile; 2-Methoxy-5-(pentafluorosulfanyl)benzonitrile; 2-Methoxy-5-SF5-benzonitrile; Benzonitrile, 2-methoxy-5-(pentafluorosulfanyl)-; 2-Methoxy-5-(pentafluorosulphanyl)benzonitrile
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(Pentafluorosulfur)Benzonitrile is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.