Description

4-(Bromomethyl)-3,5-Difluorobenzonitrile is a versatile and high-value fluorinated aromatic building block. This compound is specifically engineered for advanced organic synthesis, offering a reactive bromomethyl handle and electron-withdrawing nitrile group for precise molecular construction. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides that require fluorinated aromatic cores for enhanced activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the creation of novel fluorinated polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromomethyl group is amenable to various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for carbon-carbon bond formation.
• Nucleophilic Substitution: The benzylic bromide is highly reactive, facilitating efficient nucleophilic substitution to introduce diverse functional groups.

Basic Information

Product Name	4-(Bromomethyl)-3,5-Difluorobenzonitrile
CAS No.	1239964-16-9
Molecular Formula	C8H4BrF2N
Molecular Weight	232.03 g/mol
Synonyms	3,5-Difluoro-4-(bromomethyl)benzonitrile; 4-(Bromomethyl)-3,5-difluorobenzonitrile; Benzonitrile, 4-(bromomethyl)-3,5-difluoro-; 3,5-Difluoro-4-bromomethylbenzonitrile; 4-Bromomethyl-3,5-difluorobenzonitrile; α-Bromo-3,5-difluoro-p-tolunitrile
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)-3,5-Difluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.