Description

1,2-Difluoro-3-Methoxy-5-Nitrobenzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring strategically placed fluorine, methoxy, and nitro substituents, makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel agrochemicals, pharmaceuticals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for candidates requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Serves as a precursor in the creation of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated organic electronic materials, contributing to improved charge transport and thermal stability in display technologies.
• Dye & Pigment Manufacturing: Acts as an intermediate for producing specialized nitro- and fluoro-substituted dyes with unique color fastness and spectral properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl and heteroaryl structures.
• Academic & Contract Research: Employed in academic laboratories and CROs (Contract Research Organizations) for methodological studies and the exploration of new fluorination chemistries.

Basic Information

Product Name	1,2-Difluoro-3-Methoxy-5-Nitrobenzene
CAS No.	1235492-43-9
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	3-Methoxy-2,6-difluoronitrobenzene; 2,6-Difluoro-3-methoxynitrobenzene; 5-Nitro-1,2-difluoro-3-methoxybenzene; 1,2-Difluoro-3-methoxy-5-nitro-benzene; Benzene, 1,2-difluoro-3-methoxy-5-nitro-; 2,6-Difluoro-3-methoxy-1-nitrobenzene
EINECS	Contact for details

Quality Control

Our 1,2-Difluoro-3-Methoxy-5-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.