Description

2-Ethoxy-1-Fluoro-3-Nitrobenzene is a high-purity, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound is valued for its unique substitution pattern, which allows for selective chemical transformations in the creation of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, leveraging the nitro and fluoro substituents.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye & Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments where the nitro group acts as an auxochrome.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for biaryl formation.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups make it an excellent candidate for nucleophilic substitution reactions to introduce diverse functionalities.

Basic Information

Product Name	2-Ethoxy-1-Fluoro-3-Nitrobenzene
CAS No.	1233954-79-4
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	1-Ethoxy-2-fluoro-3-nitrobenzene; 2-Fluoro-6-ethoxynitrobenzene; 3-Nitro-2-fluoroanisole; 2-Fluoro-3-nitroanisole; 1-Fluoro-2-ethoxy-3-nitrobenzene; Benzene, 1-ethoxy-2-fluoro-3-nitro-; 2-Ethoxy-6-fluoronitrobenzene
EINECS	Contact for details

Quality Control

Every batch of 2-Ethoxy-1-Fluoro-3-Nitrobenzene is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemicals and pharmaceutical intermediates. Comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, is performed to verify identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.