Description

Sepranolone is a synthetic neurosteroid and a potent, selective antagonist of the allopregnanolone site on GABA-A receptors. This specific mechanism of action makes it a critical research tool for studying neuroendocrine pathways and stress-related disorders. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of neuroscience, endocrinology, and psychiatry. Sepranolone CAS NO 1232861-58-3 represents a high-purity standard for investigative and developmental applications.

Application

• Neuroscience Research: Used as a key pharmacological tool to investigate the role of neurosteroids like allopregnanolone in modulating GABAergic signaling and neuronal excitability.
• Psychiatric Disorder Studies: Employed in preclinical research models for conditions such as postpartum depression, anxiety, and premenstrual dysphoric disorder (PMDD) where neurosteroid fluctuations are implicated.
• Endocrinology & Pharmacology: Serves as a reference standard in studies exploring the interaction between the endocrine system and central nervous system function.
• Drug Discovery & Development: Acts as a lead compound or benchmark in the development of novel therapeutics targeting GABA-A receptor subtypes for neurological and psychiatric indications.
• Biochemical Assays: Utilized in in vitro receptor binding and functional assays to characterize compound activity and selectivity.

Basic Information

Product Name	Sepranolone
CAS No.	1232861-58-3
Molecular Formula	C21H32O3
Molecular Weight	332.48 g/mol
Synonyms	UC1010; (3S,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; 3β-Hydroxy-5β-pregnan-20-one; 5β-Pregnan-3β-ol-20-one; GABA-A receptor modulating steroid antagonist (GAMSA).
EINECS	Contact for details

Quality Control

Our Sepranolone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.