Description

3-Bromo-2-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic intermediate featuring both bromine and trifluoromethyl substituents. This compound is engineered to provide a versatile and reactive scaffold for constructing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, crop protection, and the synthesis of specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Material Science Precursor: Acts as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings to form new carbon-carbon bonds.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution on the physical and chemical properties of organic compounds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	3-Bromo-2-(Trifluoromethyl)Benzonitrile
CAS No.	1228898-24-5
Molecular Formula	C8H3BrF3N
Molecular Weight	250.02 g/mol
Synonyms	2-Bromo-6-(trifluoromethyl)benzonitrile; 3-Bromo-2-(trifluoromethyl)benzonitrile; Benzonitrile, 3-bromo-2-(trifluoromethyl)-; 2-(Trifluoromethyl)-3-bromobenzonitrile; 3-Bromo-alpha,alpha,α-trifluoro-o-tolunitrile; o-Cyano-6-bromo-alpha,alpha,α-trifluorotoluene
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-2-(Trifluoromethyl)Benzonitrile is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.