Description

(S)-2-(4-(Trifluoromethoxy)Phenyl)Piperidine is a high-purity chiral piperidine derivative, serving as a critical building block in modern organic synthesis. Its value lies in its unique trifluoromethoxy-substituted aromatic structure, which is instrumental in modulating the physicochemical properties of target molecules, such as metabolic stability and lipophilicity. This advanced pharmaceutical intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty chemicals and functional materials requiring specific fluorinated aromatic motifs.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes to study biological pathways and protein interactions.

Basic Information

Product Name	(S)-2-(4-(Trifluoromethoxy)Phenyl)Piperidine
CAS No.	1228568-83-9
Molecular Formula	C12H14F3NO
Molecular Weight	245.24 g/mol
Synonyms	(S)-2-[4-(Trifluoromethoxy)phenyl]piperidine; (S)-2-(4-Trifluoromethoxyphenyl)piperidine; (S)-α-(4-Trifluoromethoxyphenyl)piperidine; (S)-2-(4-(Trifluoromethoxy)phenyl)piperidine; (S)-2-(p-Trifluoromethoxyphenyl)piperidine; (S)-2-(4-(Trifluoromethoxy)phenyl)piperidine hydrochloride (salt form); (S)-2-(4-(Trifluoromethoxy)phenyl)piperidine HBr (salt form)
EINECS	Contact for details

Quality Control

Our (S)-2-(4-(Trifluoromethoxy)Phenyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with high-grade standards for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.