Description

4-Amino-2-Chloro-5-Fluorobenzonitrile is a high-purity, multi-functional aromatic nitrile building block. This compound is valued for its unique substitution pattern, which makes it a critical intermediate in the synthesis of complex organic molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a building block for creating specialized polymers, liquid crystals, and organic electronic materials due to its rigid, polar structure.
• Dye and Pigment Intermediate: Employed in the synthesis of complex colorants and functional dyes where the amino and cyano groups facilitate chromophore development.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) to create diverse biaryl and aniline derivatives.

Basic Information

Product Name	4-Amino-2-Chloro-5-Fluorobenzonitrile
CAS No.	1228376-68-8
Molecular Formula	C7H4ClFN2
Molecular Weight	170.57 g/mol
Synonyms	2-Chloro-5-fluoro-4-aminobenzonitrile; 4-Amino-2-chloro-5-fluorobenzene carbonitrile; 5-Fluoro-2-chloro-4-aminobenzonitrile; Benzonitrile, 4-amino-2-chloro-5-fluoro-; 2-Chloro-4-cyano-5-fluoroaniline; 4-Amino-2-chloro-5-fluorophenyl cyanide; 5-Fluoro-4-amino-2-chlorobenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Chloro-5-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.