Description

1-Bromo-2-Fluoro-4-Iodo-5-Nitrobenzene is a highly functionalized, multi-halogenated aromatic compound that serves as a critical building block in advanced organic synthesis. Its unique combination of bromo, fluoro, iodo, and nitro substituents on a single benzene ring makes it a versatile and valuable intermediate for constructing complex molecular architectures. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients, where its distinct reactivity profile enables precise structural modifications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting complex small molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed reactions (e.g., Suzuki, Stille, Sonogashira) due to the presence of bromo and iodo groups with different reactivities.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis and coordination chemistry.
• Chemical Library Development: A valuable scaffold for generating diverse compound libraries in high-throughput screening for drug discovery.

Basic Information

Product Name	1-Bromo-2-Fluoro-4-Iodo-5-Nitrobenzene
CAS No.	1226808-77-0
Molecular Formula	C6H2BrFINO2
Molecular Weight	345.89 g/mol
Synonyms	1-Bromo-2-fluoro-4-iodo-5-nitrobenzene; 2-Fluoro-4-iodo-1-bromo-5-nitrobenzene; 5-Nitro-1-bromo-2-fluoro-4-iodobenzene; Benzene, 1-bromo-2-fluoro-4-iodo-5-nitro-; CAS 1226808-77-0
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluoro-4-Iodo-5-Nitrobenzene is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality systems are designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.