Description

4-Chloro-2,3-Difluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block, identified by CAS NO 1224881-80-4. This compound is valued for its unique halogen-substituted benzonitrile structure, which provides a versatile and reactive scaffold for advanced chemical synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the difluorobenzonitrile moiety into complex molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the chloro and fluoro substituents enhance biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the development of specialty polymers with enhanced thermal and chemical resistance.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl systems.
• Chemical Research & Development: Utilized in academic and industrial R&D labs for exploring new reaction pathways and creating novel fluorinated compounds.

Basic Information

Product Name	4-Chloro-2,3-Difluorobenzonitrile
CAS No.	1224881-80-4
Molecular Formula	C7H2ClF2N
Molecular Weight	173.55 g/mol
Synonyms	2,3-Difluoro-4-chlorobenzonitrile; 4-Chloro-2,3-difluorobenzene carbonitrile; Benzonitrile, 4-chloro-2,3-difluoro-; 4-Chloro-2,3-difluorophenyl cyanide; 1224881-80-4; 4-Cl-2,3-F2-benzonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,3-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.