Description

2-Fluoro-4-Methoxy-5-Nitro-Benzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique molecular structure, featuring fluorine, methoxy, and nitro substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated aromatic core.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the nitro and cyano groups are essential for bioactivity.
• Material Science Research: Serves as a building block for advanced organic materials, such as liquid crystals, organic semiconductors, and photoactive polymers.
• Chemical Biology & Proteomics: Employed as a versatile scaffold or labeling agent in the design of molecular probes and enzyme inhibitors.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing specialized dyes and pigments with specific color and stability properties.
• Cross-Coupling Reactions: The halogen and cyano groups make it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl systems.

Basic Information

Product Name	2-Fluoro-4-Methoxy-5-Nitro-Benzonitrile
CAS No.	1224708-00-2
Molecular Formula	C8H5FN2O3
Molecular Weight	196.14 g/mol
Synonyms	5-Nitro-2-fluoro-4-methoxybenzonitrile; 2-Fluoro-4-methoxy-5-nitrobenzonitrile; Benzonitrile, 2-fluoro-4-methoxy-5-nitro-; 4-Methoxy-5-nitro-2-fluorobenzonitrile; 1224708-00-2
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Methoxy-5-Nitro-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high standards, including cGMP development and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.