Description

2-Amino-3-Iodo-5-(Trifluoromethyl)-Benzenecarbonitrile is a high-value, multi-functional aromatic building block featuring amino, cyano, iodo, and trifluoromethyl substituents. This unique combination of functional groups makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for creating novel active ingredients, as well as by material scientists exploring specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Material Science Research: Serves as a precursor for functionalized polymers, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The iodine atom provides an excellent handle for palladium-catalyzed coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry Studies: An important compound for investigating the effects of the trifluoromethyl group on molecular properties and reactivity.
• Dye and Pigment Intermediate: Potential use in synthesizing specialized dyes and pigments due to its conjugated aromatic structure with electron-withdrawing groups.

Basic Information

Product Name	2-Amino-3-Iodo-5-(Trifluoromethyl)-Benzenecarbonitrile
CAS No.	1221792-71-7
Molecular Formula	C8H4F3IN2
Molecular Weight	312.03 g/mol
Synonyms	2-Amino-3-iodo-5-(trifluoromethyl)benzonitrile; 3-Iodo-2-amino-5-(trifluoromethyl)benzonitrile; Benzonitrile, 2-amino-3-iodo-5-(trifluoromethyl)-; 2-Cyano-6-iodo-4-(trifluoromethyl)aniline; 4-Amino-3-cyano-5-iodobenzotrifluoride; 2-Amino-α,α,α-trifluoro-3-iodo-5-cyanotoluene
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Iodo-5-(Trifluoromethyl)-Benzenecarbonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as identity, purity, and impurity profiles. Our quality systems are designed to support cGMP compliance for pharmaceutical development, and we can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.