Description

1-(Trifluoromethyl)-3-Azabicyclo[3.1.0]Hexane Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique, strained bicyclic scaffold with a trifluoromethyl group. This compound is valued for its role in modulating the physicochemical and metabolic properties of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting the central nervous system and other therapeutic areas. It is primarily sought by research institutions and pharmaceutical companies engaged in the synthesis of novel bioactive molecules, where its distinct structure is leveraged to enhance potency, selectivity, and pharmacokinetic profiles.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce conformational constraint and fluorine atoms into lead compounds.
• Agrochemical Development: Serves as a precursor in the research and development of advanced pesticides and herbicides, leveraging the stability imparted by the fluorine atoms.
• Ligand Synthesis: Employed in the creation of specialized ligands for catalysis and molecular recognition applications.
• Proteolysis Targeting Chimera (PROTAC) Linkers: Utilized in the construction of heterobifunctional molecules for targeted protein degradation therapies.
• Chemical Biology Probes: Incorporated into tool compounds for investigating biological pathways and target validation.

Basic Information

Product Name	1-(Trifluoromethyl)-3-Azabicyclo[3.1.0]Hexane Hydrochloride
CAS No.	1221722-96-8
Molecular Formula	C7H9ClF3N
Molecular Weight	199.60 g/mol
Synonyms	1-(Trifluoromethyl)-3-azabicyclo[3.1.0]hexane HCl; 3-Azabicyclo[3.1.0]hexane, 1-(trifluoromethyl)-, hydrochloride; 1-(Trifluoromethyl)-3-azabicyclo[3.1.0]hexane hydrochloride; 1-(Trifluoromethyl)-3-azabicyclo[3.1.0]hexane, HCl salt; 3-Azabicyclo[3.1.0]hexane, 1-(trifluoromethyl)-, hydrochloride (1:1); 1221722-96-8; 1-Trifluoromethyl-3-azabicyclo[3.1.0]hexane hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(Trifluoromethyl)-3-Azabicyclo[3.1.0]Hexane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.