Description

2-(Trifluoromethoxy)Pyridin-4-Amine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethoxy-substituted pyridine core offers enhanced metabolic stability and lipophilicity, making it indispensable for developing novel active compounds. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating next-generation products.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group improves biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of functionalized ligands for catalysis and as a monomer for specialty polymers with unique electronic properties.
• Chemical Research & Development: Serves as a versatile building block in medicinal chemistry and process chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Liquid Crystal & OLED Materials: A potential intermediate for creating fluorinated components used in electronic display materials and organic light-emitting diodes (OLEDs).

Basic Information

Item	Details
Product Name	2-(Trifluoromethoxy)Pyridin-4-Amine
CAS No.	1221172-01-5
Molecular Formula	C6H5F3N2O
Molecular Weight	178.11 g/mol
Synonyms	4-Amino-2-(trifluoromethoxy)pyridine; 2-(Trifluoromethoxy)-4-pyridinamine; 4-Pyridinamine, 2-(trifluoromethoxy)-; 2-Trifluoromethoxypyridin-4-ylamine; 4-Amino-2-(trifluoromethoxyl)pyridine; 2-(Trifluoromethoxy)-4-aminopyridine; 4-Amino-α,α,α-trifluoro-2-pyridinemethanol methyl ether
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Pyridin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.