Description

3-Amino-4-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic intermediate featuring both an amino and a trifluoromethyl group on a benzonitrile core. This unique structure makes it a critical building block for the synthesis of advanced pharmaceutical compounds and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers with tailored electronic properties.
• Fluorinated Compound Library: An essential building block for combinatorial chemistry and high-throughput screening in drug discovery programs.
• Dye and Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments.

Basic Information

Product Name	3-Amino-4-(Trifluoromethyl)Benzonitrile
CAS No.	1220630-83-0
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	4-Amino-3-(trifluoromethyl)benzonitrile; 3-Amino-α,α,α-trifluoro-p-tolunitrile; 2-Cyano-6-(trifluoromethyl)aniline; 3-Amino-4-cyanobenzotrifluoride; Benzonitrile, 3-amino-4-(trifluoromethyl)-; 3-Amino-4-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 3-Amino-4-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.