Description

2-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetonitrile is a high-value, multi-functional boronic ester derivative, serving as a critical advanced pharmaceutical intermediate and versatile Suzuki-Miyaura cross-coupling building block. Its unique structure, featuring both a nitrile and a protected boronic acid group, enables efficient synthesis of complex molecules for drug discovery and material science. This compound is essential for R&D chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to construct novel fluorinated biaryl scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in oncology and CNS drug candidates.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds to create complex, fluorinated biaryl structures prevalent in modern medicinal chemistry.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science & OLED Development: Acts as a precursor for creating organic electronic materials, including light-emitting diodes (OLEDs) and semiconductors.
• Ligand & Catalyst Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorinated Compound Library Synthesis: A crucial reagent for combinatorial chemistry and high-throughput screening in drug discovery programs.

Basic Information

Product Name	2-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetonitrile
CAS No.	1220219-61-3
Molecular Formula	C₁₆H₂₁BFNO₂
Molecular Weight	289.16 g/mol
Synonyms	2-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile; 2-Fluoro-4-(cyanomethyl)phenylboronic acid pinacol ester; (2-Fluoro-4-(cyanomethyl)phenyl)boronic acid pinacol ester; 4-(Cyanomethyl)-2-fluorophenylboronic acid pinacol ester; 2-(2-Fluoro-4-(pinacolatoboryl)phenyl)acetonitrile; 1220219-61-3; 2-Fluoro-4-(cyanomethyl)benzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific project requirements, including ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.