Description

2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its core value proposition lies in enabling efficient and selective carbon-carbon bond formation, a fundamental step in constructing complex molecular architectures. This compound is primarily needed by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in drug discovery, catalyst development, and the synthesis of functional organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides, herbicides, and fungicides, where the introduction of the fluorinated benzonitrile moiety can enhance biological activity and environmental stability.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its ability to introduce both electron-withdrawing (cyano, fluoro) and boron-based functional groups.
• Chemical Biology & Probe Development: Serves as a versatile precursor for creating fluorescent tags, bioconjugation reagents, and molecular probes used in diagnostic assays and cellular imaging.
• Catalyst Ligand Precursor: Can be utilized to synthesize novel bidentate or monodentate ligands for transition metal catalysts used in asymmetric synthesis and other catalytic transformations.
• Academic & Contract Research: A valuable reagent for methodology development in academic laboratories and contract research organizations (CROs) focused on expanding the toolbox of synthetic organic chemistry.

Basic Information

Item	Details
Product Name	2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1218791-15-1
Molecular Formula	C₁₃H₁₅BFNO₂
Molecular Weight	247.08 g/mol
Synonyms	2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 3-Cyano-2-fluorophenylboronic acid pinacol ester; (3-Cyano-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-3-(pinacolatoboryl)benzonitrile; Pinacol (3-cyano-2-fluorophenyl)boronate; 2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl cyanide; CAS 1218791-15-1
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.