Description

(2S)-2-(3,4-Difluorophenyl)Pyrrolidine is a high-purity chiral pyrrolidine derivative, a crucial building block in modern organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, enabling the development of advanced pharmaceuticals and agrochemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce a specific chiral amine moiety into their target structures.

Application

• Pharmaceutical Intermediate: A vital chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the specific stereochemistry influences biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control reaction stereoselectivity.
• Fine Chemical Building Block: Employed in custom synthesis and contract manufacturing for creating specialty chemicals with high added value.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic chemistry and for exploring new synthetic routes in process chemistry.

Basic Information

Product Name	(2S)-2-(3,4-Difluorophenyl)Pyrrolidine
CAS No.	1217775-23-9
Molecular Formula	C10H11F2N
Molecular Weight	183.20 g/mol
Synonyms	(S)-2-(3,4-Difluorophenyl)pyrrolidine; (2S)-2-(3,4-Difluorophenyl)-1-azacyclopentane; (S)-3,4-Difluoro-α-(pyrrolidin-2-yl)benzene; 1217775-23-9; (S)-2-(3,4-Difluorophenyl)pyrrolidine; Pyrrolidine, 2-(3,4-difluorophenyl)-, (2S)-; (2S)-2-(3,4-Difluorophenyl)azacyclopentane
EINECS	Contact for details

Quality Control

Our (2S)-2-(3,4-Difluorophenyl)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.