Description

n-Boc-(2R,3R)-3-Amino-2-Hydroxy-3-(2-Trifluoromethyl-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a chiral β-hydroxy-α-amino acid scaffold with a Boc-protected amine and a trifluoromethylphenyl side chain. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, offering precise stereochemical control. It is primarily utilized by researchers and process chemists in the pharmaceutical and biotechnology industries for developing novel therapeutics, including protease inhibitors and other targeted agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Protease Inhibitor Synthesis: Serves as a core structural component in the design and synthesis of potent inhibitors for various proteolytic enzymes.
• Peptidomimetic Chemistry: Used to incorporate non-natural, sterically defined amino acid residues into peptide analogs to enhance stability, potency, and selectivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel chemical space.
• Process Chemistry & Scale-Up: Suitable for use in developing robust, scalable synthetic routes from laboratory to pilot plant scale for candidate molecules.
• Bioconjugation & Probe Development: The reactive functional groups allow for its use in creating labeled compounds or conjugates for biochemical studies.

Basic Information

Product Name	n-Boc-(2R,3R)-3-Amino-2-Hydroxy-3-(2-Trifluoromethyl-Phenyl)-Propionic Acid
CAS No.	1217762-48-5
Molecular Formula	C₁₅H₁₈F₃NO₅
Molecular Weight	349.30 g/mol
Synonyms	(2R,3R)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-[2-(trifluoromethyl)phenyl]propanoic acid; tert-Butyl (1R,2R)-1-carboxy-2-hydroxy-3-[2-(trifluoromethyl)phenyl]propylcarbamate; Boc-(2R,3R)-AHPATfp-OH; (2R,3R)-Boc-AHPATfp; β-Hydroxy-α-amino acid derivative; Chiral β-hydroxy amino acid building block; Non-natural Boc-protected amino acid
EINECS	Contact for details

Quality Control

Our n-Boc-(2R,3R)-3-Amino-2-Hydroxy-3-(2-Trifluoromethyl-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to maintain product integrity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.