Description

2-Fluoro-5-Bromo-3-Iodopyridine is a high-purity, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique reactivity profile, enabling precise molecular construction in complex chemical environments. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, leveraging the halogenated pyridine scaffold for bioactivity.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the presence of bromo and iodo substituents, allowing for sequential functionalization.
• Ligand Synthesis: Employed in the preparation of novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Used to create tagged molecules and probes for studying biological pathways and protein interactions.

Basic Information

Item	Details
Product Name	2-Fluoro-5-Bromo-3-Iodopyridine
CAS No.	1214376-88-1
Molecular Formula	C5H2BrFIN
Molecular Weight	301.88 g/mol
Synonyms	5-Bromo-3-iodo-2-fluoropyridine; 3-Iodo-5-bromo-2-fluoropyridine; 2-Fluoro-3-iodo-5-bromopyridine; Pyridine, 2-fluoro-5-bromo-3-iodo-; 1214376-88-1; FC&I-Br-Py (abbrev.); 2-F-5-Br-3-I-Py
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Bromo-3-Iodopyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.