Description

3-Fluoro-5-Phenylbenzonitrile is a high-purity fluorinated aromatic nitrile building block, identified by CAS number 1214352-57-4. This compound is valued for its unique molecular scaffold, which combines a phenyl ring with a fluorine substituent and a reactive nitrile group, making it a versatile intermediate in advanced organic synthesis. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecules, such as active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic compounds for electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Chemical Synthesis: Acts as a versatile synthon in cross-coupling reactions (e.g., Suzuki, Sonogashira) and as a precursor for converting the nitrile group into other functionalities like amides, acids, or tetrazoles.
• Academic & Industrial R&D: Employed in research laboratories for method development, catalysis studies, and exploring new chemical spaces in fluoroorganic chemistry.

Basic Information

Product Name	3-Fluoro-5-Phenylbenzonitrile
CAS No.	1214352-57-4
Molecular Formula	C13H8FN
Molecular Weight	197.21 g/mol
Synonyms	3-Fluoro-5-phenylbenzonitrile; [1,1'-Biphenyl]-3-carbonitrile, 3'-fluoro-; 3'-Fluoro-[1,1'-biphenyl]-3-carbonitrile; 3-Fluoro-5-phenyl-benzonitrile; 3-Phenyl-5-fluorobenzonitrile; 5-Fluoro-3-phenylbenzonitrile; Benzonitrile, 3-fluoro-5-phenyl-
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Phenylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.