Description

1-(Difluoromethoxy)-4-Fluoro-2-Nitro-Benzene is a specialized fluorinated aromatic nitro compound, serving as a high-value intermediate in advanced organic synthesis. Its unique difluoromethoxy and nitro substituents make it a critical building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic scaffolds to modulate bioavailability and metabolic stability.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and environmental profile.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals with specific optical or electronic properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitutions, and reduction reactions to introduce fluorinated anisole derivatives into more complex structures.
• Dye and Pigment Intermediate: Potential use in the synthesis of specialized dyes and pigments where nitro and fluorine groups influence color fastness and spectral characteristics.

Basic Information

Item	Details
Product Name	1-(Difluoromethoxy)-4-Fluoro-2-Nitro-Benzene
CAS No.	1214349-53-7
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	4-Fluoro-2-nitro-1-(difluoromethoxy)benzene; 1-(Difluoromethoxy)-4-fluoro-2-nitrobenzene; 2-Nitro-4-fluoro-1-(difluoromethoxy)benzene; α,α-Difluoro-4-fluoro-2-nitroanisole; Difluoromethyl 4-fluoro-2-nitrophenyl ether
EINECS	Contact for details

Quality Control

Our production of 1-(Difluoromethoxy)-4-Fluoro-2-Nitro-Benzene adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure consistency and meet the exacting standards required for research and process chemistry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.