Description

3-Fluoro-5-Nitrobenzyl Chloride is a versatile and highly reactive aromatic building block, primarily valued for its dual functional handles—the benzyl chloride and nitro groups—which facilitate a wide range of chemical transformations. This compound is essential for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorinated and nitro-substituted motifs into their target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing complex nitro- and fluoro-substituted dyes and pigments.
• Cross-coupling Reactions: The benzyl chloride moiety is useful in various palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.

Basic Information

Product Name	3-Fluoro-5-Nitrobenzyl Chloride
CAS No.	1214344-25-8
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	1-(Chloromethyl)-3-fluoro-5-nitrobenzene; (3-Fluoro-5-nitrophenyl)methyl chloride; α-Chloro-3-fluoro-5-nitrotoluene; 3-Fluoro-5-nitrobenzylchloride; 3-Fluoro-5-nitrobenzyl chloride; Benzene, 1-(chloromethyl)-3-fluoro-5-nitro-; 3-Fluoro-5-nitrobenzyl chloride (major)
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Nitrobenzyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive characterization and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for identity, purity, and related substances. Our quality management system is designed to meet the rigorous standards required for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.