Description

1-Fluoro-3-Nitro-2-(Trifluoromethyl)Benzene is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and nitro substituents, which are critical for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex, light-fast fluorinated dyes and organic pigments.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorine Chemistry Library Building: Essential for constructing diverse compound libraries in medicinal chemistry for structure-activity relationship (SAR) studies.

Basic Information

Item	Details
Product Name	1-Fluoro-3-Nitro-2-(Trifluoromethyl)Benzene
CAS No.	1214342-08-1
Molecular Formula	C7H3F4NO2
Molecular Weight	209.10 g/mol
Synonyms	2-(Trifluoromethyl)-1-fluoro-3-nitrobenzene; 1-Fluoro-3-nitro-2-(trifluoromethyl)benzene; 2-Trifluoromethyl-1-fluoro-3-nitrobenzene; 3-Nitro-2-(trifluoromethyl)fluorobenzene; 2-Fluoro-6-nitrobenzotrifluoride; α,α,α-Trifluoro-2-fluoro-6-nitro toluene; Benzene, 1-fluoro-3-nitro-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-Fluoro-3-Nitro-2-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and GC-MS and NMR for identity confirmation, to ensure it meets precise customer specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to the nitro and fluorine substituents, store separately from strong bases, reducing agents, and combustible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.