Description

5-Nitro-2-(Trifluoromethoxy)Benzonitrile is a high-value, multi-functional aromatic intermediate featuring both nitro and trifluoromethoxy substituents. This compound is critical for synthesizing advanced materials and active pharmaceutical ingredients (APIs) due to its unique electronic properties and stability imparted by the fluorine atoms. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds with enhanced biological activity and material characteristics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the trifluoromethoxy group improves lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for advanced electronic materials, contributing to the molecular framework of dyes and charge-transport materials.
• Organic Synthesis & Chemical Research: A versatile reagent for introducing nitro and trifluoromethoxy functionalities into complex molecular architectures in academic and industrial R&D.
• Coordination Chemistry: Potential ligand precursor for metal-organic frameworks (MOFs) and catalysts due to its nitrile and electron-withdrawing groups.

Basic Information

Product Name	5-Nitro-2-(Trifluoromethoxy)Benzonitrile
CAS No.	1214341-32-8
Molecular Formula	C8H3F3N2O3
Molecular Weight	232.12 g/mol
Synonyms	2-(Trifluoromethoxy)-5-nitrobenzonitrile; 5-Nitro-α,α,α-trifluoro-o-anisonitrile; Benzonitrile, 5-nitro-2-(trifluoromethoxy)-; 2-Trifluoromethoxy-5-nitrobenzonitrile; 5-Nitro-2-trifluoromethoxybenzonitrile; 1214341-32-8; 5-Nitro-2-(trifluoromethoxy)benzonitrile
EINECS	Contact for details

Quality Control

Every batch of 5-Nitro-2-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with relevant industry standards for fine chemical intermediates. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.