Description

3-(4-Fluorophenyl)Picolinonitrile is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is a critical strategy for modulating biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate sophisticated, functionalized aromatic systems into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of drug candidates, particularly kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the fluorine substituent.
• Material Science: Acts as a building block for creating advanced organic electronic materials, such as ligands for OLEDs or molecular semiconductors.
• Chemical Biology: Employed as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies.
• Custom Synthesis: Provides a versatile starting point for contract research organizations (CROs) and CDMOs to synthesize complex, bespoke molecules for clients.

Basic Information

Product Name	3-(4-Fluorophenyl)Picolinonitrile
CAS No.	1214340-31-4
Molecular Formula	C₁₂H₇FN₂
Molecular Weight	198.20 g/mol
Synonyms	3-(4-Fluorophenyl)-2-pyridinecarbonitrile; 2-Cyano-3-(4-fluorophenyl)pyridine; 3-(4-Fluorophenyl)picolinonitrile; 2-Pyridinecarbonitrile, 3-(4-fluorophenyl)-; Picolinonitrile, 3-(4-fluorophenyl)-; 1214340-31-4; 3-(p-Fluorophenyl)picolinonitrile
EINECS	Contact for details

Quality Control

Our 3-(4-Fluorophenyl)Picolinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly closed and stored in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.