Description

1-(Difluoromethoxy)-3-Fluoro-2-Nitro-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both difluoromethoxy and nitro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the difluoromethoxy pharmacophore.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging its aromatic and fluorinated characteristics.
• Organic Electronics: Investigated as a building block for electron-deficient materials used in organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The nitro and halogen groups provide handles for versatile metal-catalyzed coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Fluorine Chemistry Studies: An important reagent for academic and industrial research focused on the synthesis and reactivity of fluorinated aromatic compounds.

Basic Information

Product Name	1-(Difluoromethoxy)-3-Fluoro-2-Nitro-Benzene
CAS No.	1214336-89-6
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	3-Fluoro-2-nitro-1-(difluoromethoxy)benzene; 1-(Difluoromethoxy)-3-fluoro-2-nitrobenzene; Benzene, 1-(difluoromethoxy)-3-fluoro-2-nitro-; 2-Nitro-3-fluoroanisole, difluoro; 3-Fluoro-2-nitrophenyl difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-3-Fluoro-2-Nitro-Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.