Description

4-(Difluoromethoxy)-2-Fluoro-1-Nitro-Benzene is a high-purity fluorinated aromatic nitro compound, serving as a critical building block in advanced organic synthesis. Its unique difluoromethoxy and fluoro substituents make it a valuable intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates requiring fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, where fluorine atoms contribute to thermal stability, chemical resistance, and specific optical properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitutions, and reduction reactions to construct complex, fluorinated molecular architectures.

Basic Information

Product Name	4-(Difluoromethoxy)-2-Fluoro-1-Nitro-Benzene
CAS No.	1214336-83-0
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	2-Fluoro-4-(difluoromethoxy)-1-nitrobenzene; 1-Nitro-2-fluoro-4-(difluoromethoxy)benzene; Benzene, 2-fluoro-1-nitro-4-(difluoromethoxy)-; 4-(Difluoromethoxy)-2-fluoronitrobenzene
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethoxy)-2-Fluoro-1-Nitro-Benzene is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.