Description

2-Bromo-4-(Trifluoromethoxy)Benzonitrile is a versatile and high-value aromatic nitrile building block, distinguished by its bromine and trifluoromethoxy substituents. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in cross-coupling reactions, ligand synthesis, and as a precursor for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl structures.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel phosphine or nitrogen-based ligands for catalytic systems.
• Chemical Biology Probes: Employed in the creation of fluorescent tags or molecular probes for biochemical and diagnostic research.

Basic Information

Product Name	2-Bromo-4-(Trifluoromethoxy)Benzonitrile
CAS No.	1214334-83-4
Molecular Formula	C8H3BrF3NO
Molecular Weight	266.02 g/mol
Synonyms	2-Bromo-4-(trifluoromethoxy)benzonitrile; 4-Bromo-2-(trifluoromethoxy)benzonitrile; Benzonitrile, 2-bromo-4-(trifluoromethoxy)-; 2-Bromo-α,α,α-trifluoro-p-anisonitrile; 1214334-83-4; 2-Bromo-4-trifluoromethoxy-benzonitrile
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.