Description

2-(Difluoromethyl)-4-Fluoro-1-Nitrobenzene is a high-purity fluorinated aromatic nitro compound, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both difluoromethyl and nitro functional groups on a fluorinated benzene ring, makes it a versatile intermediate for creating complex molecules with tailored properties. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty materials sectors, where precise fluorination is required to modulate bioactivity, stability, and physical characteristics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives where fluorination enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in developing novel herbicides, fungicides, and insecticides, where the difluoromethyl group can improve lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Polymer & Functional Material Modifier: Incorporated into specialty polymers to enhance chemical resistance, lower surface energy, or introduce specific reactive sites for further functionalization.
• Organic Synthesis & Catalysis Research: A valuable substrate for methodological development in cross-coupling reactions, nucleophilic aromatic substitution (SNAr), and fluorination chemistry studies.

Basic Information

Product Name	2-(Difluoromethyl)-4-Fluoro-1-Nitrobenzene
CAS No.	1214333-17-1
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	4-Fluoro-2-(difluoromethyl)-1-nitrobenzene; 1-Fluoro-4-(difluoromethyl)-2-nitrobenzene; 2-Nitro-5-fluorobenzylidene difluoride; Benzene, 2-(difluoromethyl)-4-fluoro-1-nitro-; (Difluoromethyl)-4-fluoronitrobenzene
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethyl)-4-Fluoro-1-Nitrobenzene is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents and bases. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.