Description

2-(Difluoromethoxy)-4-Fluoro-1-Nitrobenzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its unique difluoromethoxy and nitro substituents, which are key motifs for modulating the physicochemical and biological properties of target molecules. It is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and CNS-active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and electronic materials.
• Chemical Research: Employed in academic and industrial laboratories for method development, catalysis studies, and exploring novel fluorination chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	2-(Difluoromethoxy)-4-Fluoro-1-Nitrobenzene
CAS No.	1214329-62-0
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	4-Fluoro-2-(difluoromethoxy)-1-nitrobenzene; 1-Nitro-2-(difluoromethoxy)-4-fluorobenzene; Benzene, 2-(difluoromethoxy)-4-fluoro-1-nitro-; 1214329-62-0; 2-(Difluoromethoxy)-4-fluoronitrobenzene
EINECS	Contact for details

Quality Control

Our production of 2-(Difluoromethoxy)-4-Fluoro-1-Nitrobenzene adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development from research to commercial scale with material suitable for GMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.