Description

2-(Difluoromethoxy)-1-Fluoro-3-Nitro-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine and difluoromethoxy groups can dramatically alter biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate these valuable motifs into novel molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where fluorinated compounds often exhibit enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating fluorinated aromatic cores used in electronic display technologies and organic semiconductors.
• Fluorinated Polymer Research: Employed in the synthesis of monomers for specialty polymers with unique chemical resistance, thermal stability, and optical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes and tags for studying biological mechanisms and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A valuable substrate for custom chemical synthesis services catering to the needs of biotechnology and material science companies.

Basic Information

Product Name	2-(Difluoromethoxy)-1-Fluoro-3-Nitro-Benzene
CAS No.	1214326-22-3
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	1-Fluoro-2-(difluoromethoxy)-3-nitrobenzene; 3-Nitro-2-(difluoromethoxy)fluorobenzene; Benzene, 2-(difluoromethoxy)-1-fluoro-3-nitro-; 2-(Difluoromethoxy)-1-fluoro-3-nitrobenzene; 1-Fluoro-3-nitro-2-(difluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-1-Fluoro-3-Nitro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.